解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The physical characteristics of tumours are intricately linked to the tumour phenotype and difficulties during treatment. Many factors contribute to the increased stiffness of tumours; from increased matrix deposition, matrix remodelling by forces from cancer cells and stromal fibroblasts, matrix crosslinking, increas...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/s41556-018-0131-2
更新日期:2018-07-01 00:00:00
abstract::Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to diminished ribosome biogenesis and the accumulation of both rRNA precursors and ribosomal proteins. These defects were associated with red...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0127-y
更新日期:2018-07-01 00:00:00
abstract::The contribution of autophagy to cancer development remains controversial, largely owing to the fact that autophagy can be tumour suppressive or oncogenic in different biological contexts. Here, we show that in non-small-cell lung cancer (NSCLC), casein kinase 1 alpha 1 (CK1α) suppresses tumour growth by functioning a...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0065-8
更新日期:2018-04-01 00:00:00
abstract::Somatic cell reprogramming by exogenous factors requires cooperation with transcriptional co-activators and co-repressors to effectively remodel the epigenetic environment. How this interplay is regulated remains poorly understood. Here, we demonstrate that NCoR/SMRT co-repressors bind to pluripotency loci to create a...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0047-x
更新日期:2018-04-01 00:00:00
abstract::The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By employing asymmetric flow field-flow fractionation (AF4), we identified two exosome subpopulations (large exosome vesicles, Exo-L, 90-120 nm; small exosome vesicles, Ex...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-018-0040-4
更新日期:2018-03-01 00:00:00
abstract::Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the pathogenesis of common late-onset disorders, but how they arise is not clear1,2. Here we show that mtDNA mutations are present in primordial germ cells (PGCs) within healthy female human embryos. Isolated PGCs have a profound reduct...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-017-0017-8
更新日期:2018-02-01 00:00:00
abstract::The resolution of joint molecules that link recombining sister chromatids is essential for chromosome segregation. Here, we determine the fate of unresolved recombination intermediates arising in cells lacking two nucleases required for resolution (GEN1 -/- knockout cells depleted of MUS81). We find that intermediates...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-017-0011-1
更新日期:2018-01-01 00:00:00
abstract::Re-establishment of nuclear structure and chromatin organization after cell division is integral for genome regulation or development and is frequently altered during cancer progression. The mechanisms underlying chromatin expansion in daughter cells remain largely unclear. Here, we describe the transient formation of...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3641
更新日期:2017-12-01 00:00:00
abstract::Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions. ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3645
更新日期:2017-11-29 00:00:00
abstract::The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome regulation. Here we describe the biochemical and genetic principles of how meta...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb3629
更新日期:2017-11-01 00:00:00
abstract::The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes genomic stability in BRCA1/2-deficient cancers. D...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3626
更新日期:2017-11-01 00:00:00
abstract::Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induced macrophage and ne...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3613
更新日期:2017-10-01 00:00:00
abstract::The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb3611
更新日期:2017-10-01 00:00:00
abstract::The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in r...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3619
更新日期:2017-09-29 00:00:00
abstract::Structural maintenance of chromosomes (SMC) protein complexes are key determinants of chromosome conformation. Using Hi-C and polymer modelling, we study how cohesin and condensin, two deeply conserved SMC complexes, organize chromosomes in the budding yeast Saccharomyces cerevisiae. The canonical role of cohesin is t...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3594
更新日期:2017-09-01 00:00:00
abstract::Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a number of intrinsic and extrinsic mechanisms. Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism a...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3575
更新日期:2017-09-01 00:00:00
abstract::Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory element...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3591
更新日期:2017-08-31 00:00:00
abstract::The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3573
更新日期:2017-08-01 00:00:00
abstract::Endothelial cells and leptin receptor+ (LepR+) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bone marrow adipocytes sy...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3570
更新日期:2017-08-01 00:00:00
abstract::Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalie...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3534
更新日期:2017-06-01 00:00:00
abstract::The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion,...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb3524
更新日期:2017-05-31 00:00:00
abstract::Dozens of proteins capture, polymerize and reshape the clathrin lattice during clathrin-mediated endocytosis (CME). How or if this ensemble of proteins is organized in relation to the clathrin coat is unknown. Here, we map key molecules involved in CME at the nanoscale using correlative super-resolution light and tran...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3498
更新日期:2017-04-01 00:00:00
abstract::Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol. The rhomboid protease PARL, an intramembrane cleaving peptidase in the inner membrane, regulates mitophagy and plays an ill-defined role in apoptosis. Here, we employed PARL-based proteomics to define its s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3488
更新日期:2017-04-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion. Force transmission is mediated by a heterophilic adhesion involving N-cadherin at the CAF membrane and E-cadherin at the cancer cell membrane. Th...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3478
更新日期:2017-03-01 00:00:00
abstract::Although myosin II filaments are known to exist in non-muscle cells, their dynamics and organization are incompletely understood. Here, we combined structured illumination microscopy with pharmacological and genetic perturbations, to study the process of actomyosin cytoskeleton self-organization into arcs and stress f...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3466
更新日期:2017-02-01 00:00:00
abstract::Chromosome missegregation into a micronucleus can cause complex and localized genomic rearrangements known as chromothripsis, but the underlying mechanisms remain unresolved. Here we developed an inducible Y centromere-selective inactivation strategy by exploiting a CENP-A/histone H3 chimaera to directly examine the f...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3450
更新日期:2017-01-01 00:00:00
abstract::Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The number of HSC clones born has been estimated through transplantation, but experimental approaches to assess the absolute number of forming HSCs in a native setting have remained challenging. Here, we applied single-cell and clonal...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3444
更新日期:2017-01-01 00:00:00
abstract::Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process,...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3458
更新日期:2016-12-23 00:00:00
abstract::Direct reprogramming by forced expression of transcription factors can convert one cell type into another. Thus, desired cell types can be generated bypassing pluripotency. However, direct reprogramming towards renal cells remains an unmet challenge. Here, we identify renal cell fate-inducing factors on the basis of t...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3437
更新日期:2016-12-01 00:00:00
abstract::The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication stress response protein in two proteomic screens. ETAA1-deficient c...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3415
更新日期:2016-11-01 00:00:00
abstract::The actin cable is a supracellular structure that embryonic epithelia produce to close gaps. However, the action of the cable remains debated. Here, we address the function of the cable using Drosophila dorsal closure, a paradigm to understand wound healing. First, we show that the actin cytoskeleton protein Zasp52 is...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3421
更新日期:2016-11-01 00:00:00
abstract::The polarity protein Scribble (SCRIB) regulates apical-basal polarity, directional migration and tumour suppression in Drosophila and mammals. Here we report that SCRIB is an important regulator of myeloid cell functions including bacterial infection and inflammation. SCRIB interacts directly with the NADPH oxidase (N...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3413
更新日期:2016-11-01 00:00:00
abstract::Lysosomes respond to environmental cues by controlling their own biogenesis, but the underlying mechanisms are poorly understood. Here we describe a protein kinase C (PKC)-dependent and mTORC1-independent mechanism for regulating lysosome biogenesis, which provides insights into previously reported effects of PKC on l...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3407
更新日期:2016-10-01 00:00:00
abstract::Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence is accompanied by a dynamic fluctuation of NOTCH1 activity, which drives a TGF-β-rich s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3397
更新日期:2016-09-01 00:00:00
abstract::Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal cargo i...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3386
更新日期:2016-08-01 00:00:00
abstract::Numerous cellular functions depend on actin filament (F-actin) disassembly. The best-characterized disassembly proteins, the ADF (actin-depolymerizing factor)/cofilins (encoded by the twinstar gene in Drosophila), sever filaments and recycle monomers to promote actin assembly. Cofilin is also a relatively weak actin d...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3390
更新日期:2016-08-01 00:00:00
abstract::p53 mutations occur very frequently in human cancer. Besides abrogating the tumour suppressive functions of wild-type p53, many of those mutations also acquire oncogenic gain-of-function activities. Augmentation of proteasome activity is now reported as a common gain-of-function mechanism shared by different p53 mutan...
journal_title:Nature cell biology
pub_type: 新闻
doi:10.1038/ncb3392
更新日期:2016-07-27 00:00:00
abstract::Phosphatase and tensin homologue (Pten) suppresses neoplastic growth by negatively regulating PI(3)K signalling through its phosphatase activity. To gain insight into the actions of non-catalytic Pten domains in normal physiological processes and tumorigenesis, we engineered mice lacking the PDZ-binding domain (PDZ-BD...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3369
更新日期:2016-07-01 00:00:00
abstract::Cellular transformation and cancer progression is accompanied by changes in the metabolic landscape. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewir...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3357
更新日期:2016-06-01 00:00:00
abstract::Pluripotent stem cells (PSCs) may provide a potential source of haematopoietic stem/progenitor cells (HSPCs) for transplantation; however, unknown molecular barriers prevent the self-renewal of PSC-HSPCs. Using two-step differentiation, human embryonic stem cells (hESCs) differentiated in vitro into multipotent haemat...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3354
更新日期:2016-06-01 00:00:00